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Image Search Results
Journal: bioRxiv
Article Title: Anti-SARS-CoV-2 swine glyco-humanized polyclonal antibody XAV-19 retains neutralizing activity against SARS-CoV-2 B.1.1.529 (Omicron)
doi: 10.1101/2022.01.26.477856
Figure Lengend Snippet: Amino acid sequence of the SARS-CoV-2 spike RBD variant Omicron and XAV-19 target epitopes (amino acid sequence numbered according to DBSOURCE sequence reference NC_045512.2). As previously described, all peptides are potential targets of XAV-19 antibodies as measured by peptide scanning, with binding intensity reflected by the font size (small font, weak binding to the corresponding peptides; medium font, medium binding; large font, strong binding). Underlined epitopes are XAV-19 target epitopes also confirmed by proteolytic epitope mapping (Vanhove et al, Front. Immunol.). Blue amino acids: amino acids in contact with ACE-2, according to Jafary et al. 28 . Amino acids highlighted in red: mutations found in Omicron, differentiating from the original Wuhan RBD.
Article Snippet: Recombinant Spike molecules of the Wuhan type (Sino Biological ref 40591-V08H), mutation-containing
Techniques: Sequencing, Variant Assay, Binding Assay